Neo-Inuit strategies for ensuring food security during the Little Ice Age climate change episode, Foxe Basin, Arctic Canada

This paper examines Neo-Inuit (ca. AD 1250 to present) responses to the decreased temperatures of the Little Ice Age (LIA) climate change episode (ca. AD 1300–1900) in the Foxe Basin region of central Nunavut, Arctic Canada. Cooler temperatures (and increased sea ice) would be expected to have reduced both bowhead whale (Balaena mysticetus) and Atlantic walrus (Odobenus rosmarus rosmarus) habitats, forcing Neo-Inuit to refocus their hunting activities on landfast-ice-dwelling small seals (e.g., Pusa hispida) during winter months. However, an analysis of faunal remains from Foxe Basin's largest-known Neo-Inuit (Thule, historic and modern Inuit) archaeological site, Pingiqqalik (NgHd-1), reveals a long-term subsistence economy based largely on multi-seasonal walrus hunting. Two interrelated factors may explain these results: (1) a system of recurring polynyas provided a degree of ecological stability for local walrus populations, and (2) the development of a distinctive walrus caching regime—a form of which continues among the region's contemporary Inuit—allowed residents to adeptly exploit an ecological niche, thereby ensuring food security. Together, these factors likely insulated northern Foxe Basin Neo-Inuit from the worst effects of the LIA

Looking back while moving forward:How past responses to climate change can inform future adaptation and mitigation strategies in the Arctic

Modern Arctic Indigenous peoples face many interconnected pressures, not the least of which is anthropogenic climate change, which is emerging as one of the most dramatic drivers of social and economic change in recent memory. In this paper, we investigate whether or not insights into premodern strategies for coping with climate change—and especially the “deeper histories” of traditional ways-of-knowing—can play a useful role in future planning, management and mitigation efforts. We do this in two ways. First, we assess this special issue's 17 archaeological case studies, in order to determine whether they are conducted within a framework that is consistent with approaches to resilience in studies of modern Arctic communities. Second, we focus on three climate-driven challenges faced by Canadian Arctic Inuit: safe travel, food security and food safety. For each, we identify specific ways in which studies of past social-ecological systems intersect with modern climate adaptation. We conclude that since archaeological insights highlight the operation of decision-making processes within long-term culture-adaptive trajectories, they can offer unique insights into the much shorter-term processes currently underway. While we highlight many potential directions for productive collaboration, much more work is required in local and regional settings to demonstrate the full potential of archaeology for future-oriented planning and mitigation efforts

Editorial: Long-Term Perspectives on Circumpolar Social-Ecological Systems

Modern climate change is having profound environmental impacts at the world's higher latitudes, leading to the disappearance of sea ice, the melting of permafrost and the northward shift of major biogeographic zones. These changing conditions have consequences for contemporary Arctic Indigenous peoples and their traditional lifeways. As planning and mitigation efforts intensify, there is renewed interest in looking back through time to understand how past Arctic societies were able to maintain a long-term—and often highly-resilient —presence in these ever-changing ecosystems. Of particular interest is how past groups coped with earlier changes in climate, both shorter-term “shocks” as well as longer-term up- and downturns in temperatures. A number of recent publications have highlighted the abundance of high-resolution and human-scale data that archaeology is uniquely positioned to contribute to this discussion (Riede, 2014; Jackson et al., 2018; Fitzhugh et al., 2018). So far, however, the practical integration of such long-term “paleo-” perspectives on specific future-orientated planning and management efforts has been limited. For example, the Arctic Council's Arctic Resilience Report (2016)—an in-depth comparative analysis of fragility and resilience in numerous local circumpolar social-ecological systems—acknowledges the importance of “deep history”, and the role of flexibility and traditional knowledge, while the chronological coverage of all 25 local case-studies remains firmly rooted in the present and very recent historical past. The overarching aim of this Special Issue is to explore the gap in knowledge between archaeological understandings of long-term Arctic adaptations and the practical application of these insights to the future-oriented challenges of sustainability and cultural survival. The first objective is to illustrate the wealth and diversity of archaeological research that is currently taking place in both the northern and southern polar regions. The issue showcases a selection of case-studies focusing on long-term human-environment interactions, integrating archaeological, climatic and paleoecological datasets. A wide range of insights emerge in terms of cultural responses to specific climatic fluctuations, but also in terms of longer-term cultural trajectories, including major shifts in settlement, subsistence, demography and interaction networks, all of which can be understood in terms of fragility and resilience in particular social-ecological systems. Another objective of the volume is to stimulate reflection and debate about what these archaeological datasets—and the long-term insights that emerge—can contribute to future planning and mitigation efforts. Seventeen papers in this issue “look back”, examining human-environment interactions in three regions: Arctic Eurasia; Arctic North America and Greenland; and Sub-Antarctic South America. Conversely, three papers “look ahead”, exploring emerging challenges and future implications. We conclude this editorial with a series of recommendations – or “action points” – that are addressed to the wider interdisciplinary research community

Genome Diversity, Recombination, and Virulence across the Major Lineages of Paracoccidioides

We thank Angela Restrepo, Rosana Puccia, Zoilo Pires de Camargo, and Maria Sueli Felipe for kindly providing the isolates for this study. This project has been funded in whole or in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract no. HHSN272200900018C. This work was partly supported by Colciencias via the grants “A Gene Atlas for Human Pathogenic Fungi” (122256934875) and “A Comprehensive Genomic and Transcriptomic Analysis of Dimorphic Human Pathogen Fungi and Its Relation with Virulence” (221365842971) and by the Universidad de Antioquia via a “Sostenibilidad 2015/2016” grant. Colciencias National Doctorate Program funding supported J.F.M.; Enlaza Mundos partly supported his fellowship. The Wellcome Trust supported R.A.F.Peer reviewedPublisher PD

An X-Ray-Selected Sample of Candidate Black Holes in Dwarf Galaxies

We present a sample of hard X-ray-selected candidate black holes (BHs) in 19 dwarf galaxies. BH candidates are identified by cross-matching a parent sample of ~44,000 local dwarf galaxies (M* = 3 × 10 9 M☉, z < 0.055) with the Chandra Source Catalog and subsequently analyzing the original X-ray data products for matched sources. Of the 19 dwarf galaxies in our sample, eight have X-ray detections reported here for the first time. We find a total of 43 point-like hard X-ray sources with individual luminosities L2-10 keV ~ 10 37 - 10 40 erg s-1. Hard X-ray luminosities in this range can be attained by stellar-mass X-ray binaries (XRBs) and by massive BHs accreting at low Eddington ratio. We place an upper limit of 53% (10/19) on the fraction of galaxies in our sample hosting a detectable hard X-ray source consistent with the optical nucleus, although the galaxy center is poorly defined in many of our objects. We also find that 42% (8/19) of the galaxies in our sample exhibit statistically significant enhanced hard X-ray emission relative to the expected galaxy-wide contribution from low-mass and high-mass XRBs, based on the [data] star formation rate relation defined by more massive and luminous systems. For the majority of these X-ray-enhanced dwarf galaxies, the excess emission is consistent with (but not necessarily due to) a nuclear X-ray source. Follow-up observations are necessary to distinguish between stellar-mass XRBs and active galactic nuclei powered by more massive BHs. In any case, our results support the notion that X-ray-emitting BHs in low-mass dwarf galaxies may have had an appreciable impact on reionization in the early universe

The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions.

Objective: With the increasing societal awareness of the prevalence and impact of acute pain, there is a need to develop an acute pain classification system that both reflects contemporary mechanistic insights and helps guide future research and treatment. Existing classifications of acute pain conditions are limiting, with a predominant focus on the sensory experience (e.g., pain intensity) and pharmacologic consumption. Consequently, there is a need to more broadly characterize and classify the multidimensional experience of acute pain. Setting: Consensus report following expert panel involving the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), American Pain Society (APS), and American Academy of Pain Medicine (AAPM). Methods: As a complement to a taxonomy recently developed for chronic pain, the ACTTION public-private partnership with the US Food and Drug Administration, the APS, and the AAPM convened a consensus meeting of experts to develop an acute pain taxonomy using prevailing evidence. Key issues pertaining to the distinct nature of acute pain are presented followed by the agreed-upon taxonomy. The ACTTION-APS-AAPM Acute Pain Taxonomy will include the following dimensions: 1) core criteria, 2) common features, 3) modulating factors, 4) impact/functional consequences, and 5) putative pathophysiologic pain mechanisms. Future efforts will consist of working groups utilizing this taxonomy to develop diagnostic criteria for a comprehensive set of acute pain conditions. Perspective: The ACTTION-APS-AAPM Acute Pain Taxonomy (AAAPT) is a multidimensional acute pain classification system designed to classify acute pain along the following dimensions: 1) core criteria, 2) common features, 3) modulating factors, 4) impact/functional consequences, and 5) putative pathophysiologic pain mechanisms. Conclusions: Significant numbers of patients still suffer from significant acute pain, despite the advent of modern multimodal analgesic strategies. Mismanaged acute pain has a broad societal impact as significant numbers of patients may progress to suffer from chronic pain. An acute pain taxonomy provides a much-needed standardization of clinical diagnostic criteria, which benefits clinical care, research, education, and public policy. For the purposes of the present taxonomy, acute pain is considered to last up to seven days, with prolongation to 30 days being common. The current understanding of acute pain mechanisms poorly differentiates between acute and chronic pain and is often insufficient to distinguish among many types of acute pain conditions. Given the usefulness of the AAPT multidimensional framework, the AAAPT undertook a similar approach to organizing various acute pain conditions

Comparative Genomic Analysis of Human Fungal Pathogens Causing Paracoccidioidomycosis

Paracoccidioides is a fungal pathogen and the cause of paracoccidioidomycosis, a health-threatening human systemic mycosis endemic to Latin America. Infection by Paracoccidioides, a dimorphic fungus in the order Onygenales, is coupled with a thermally regulated transition from a soil-dwelling filamentous form to a yeast-like pathogenic form. To better understand the genetic basis of growth and pathogenicity in Paracoccidioides, we sequenced the genomes of two strains of Paracoccidioides brasiliensis (Pb03 and Pb18) and one strain of Paracoccidioides lutzii (Pb01). These genomes range in size from 29.1 Mb to 32.9 Mb and encode 7,610 to 8,130 genes. To enable genetic studies, we mapped 94% of the P. brasiliensis Pb18 assembly onto five chromosomes. We characterized gene family content across Onygenales and related fungi, and within Paracoccidioides we found expansions of the fungal-specific kinase family FunK1. Additionally, the Onygenales have lost many genes involved in carbohydrate metabolism and fewer genes involved in protein metabolism, resulting in a higher ratio of proteases to carbohydrate active enzymes in the Onygenales than their relatives. To determine if gene content correlated with growth on different substrates, we screened the non-pathogenic onygenale Uncinocarpus reesii, which has orthologs for 91% of Paracoccidioides metabolic genes, for growth on 190 carbon sources. U. reesii showed growth on a limited range of carbohydrates, primarily basic plant sugars and cell wall components; this suggests that Onygenales, including dimorphic fungi, can degrade cellulosic plant material in the soil. In addition, U. reesii grew on gelatin and a wide range of dipeptides and amino acids, indicating a preference for proteinaceous growth substrates over carbohydrates, which may enable these fungi to also degrade animal biomass. These capabilities for degrading plant and animal substrates suggest a duality in lifestyle that could enable pathogenic species of Onygenales to transfer from soil to animal hosts.National Institute of Allergy and Infectious Diseases (U.S.)National Institutes of Health. Department of Health and Human Services (contract HHSN266200400001C)National Institutes of Health. Department of Health and Human Services(contract HHSN2722009000018C)Brazil. National Council for Scientific and Technological Developmen

Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement

Many questions regarding the clinical management of people experiencing pain and related health policy decision-making may best be answered by pragmatic controlled trials. To generate clinically relevant and widely applicable findings, such trials aim to reproduce elements of routine clinical care or are embedded within clinical workflows. In contrast with traditional efficacy trials, pragmatic trials are intended to address a broader set of external validity questions critical for stakeholders (clinicians, healthcare leaders, policymakers, insurers, and patients) in considering the adoption and use of evidence-based treatments in daily clinical care. This article summarizes methodological considerations for pragmatic trials, mainly concerning methods of fundamental importance to the internal validity of trials. The relationship between these methods and common pragmatic trials methods and goals is considered, recognizing that the resulting trial designs are highly dependent on the specific research question under investigation. The basis of this statement was an Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) systematic review of methods and a consensus meeting. The meeting was organized by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership. The consensus process was informed by expert presentations, panel and consensus discussions, and a preparatory systematic review. In the context of pragmatic trials of pain treatments, we present fundamental considerations for the planning phase of pragmatic trials, including the specification of trial objectives, the selection of adequate designs, and methods to enhance internal validity while maintaining the ability to answer pragmatic research questions